The Absolutely True Diary of a Part-Time Indian is ostensibly a book about one kid, born on the reservation, but now leaving it to go to a better school. However, it is also about how Indians fit into the wider world (in his school, "the only other Indian is the school mascot"), and life on the rez (alcoholism, casinos, education, pretty much anything). This was the first book I read where one story is in the middle of another, larger story, and it's probably the one that's done it best so far.
